Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | LMNA | P02545 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879968 | 1.00 | MAPT (0.50) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5879609 | 0.90 | GAA (0.53) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5879610 | 0.90 | GAA (0.53) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5879987 | 0.89 | MAPT (0.58) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5879992 | 0.89 | MAPT (0.58) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5880042 | 0.85 | LMNA (0.45) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5880048 | 0.85 | LMNA (0.45) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5880034 | 0.82 | MAPT (0.44) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5880039 | 0.82 | MAPT (0.44) | MAPTLMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5880011 | 0.79 | MAPT (0.42) | MAPTLMNACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026339-B2 | Inhibitors of HCV NS5B polymerase | PFIZER INC. | 2006-04-11 | — | — | US | disclosed |