Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 3/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ITGAM | P11215 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18935981 | 0.72 | LMNA (0.44) | LMNAMIFRAB9AHDAC3HDAC1 | |
| SCHEMBL31308703 | 0.69 | LMNA (0.38) | LMNAMIFF10 | |
| SCHEMBL9936193 | 0.67 | MIF (0.47) | LMNAMIFITGB3ITGA2BITGB2 | |
| SCHEMBL18935961 | 0.66 | LMNA (0.50) | LMNAMIFITGB3ITGA2BRAB9A | |
| SCHEMBL13045925 | 0.65 | — | — | |
| SCHEMBL9548274 | 0.65 | POLB (0.46) | LMNAITGB3ITGA2B | |
| SCHEMBL18936052 | 0.64 | LMNA (0.48) | LMNAMIFITGB3ITGA2BHDAC3 | |
| SCHEMBL17490744 | 0.62 | HDAC1 (0.49) | LMNAMIFITGB3ITGA2BHDAC3 | |
| SCHEMBL7437566 | 0.62 | — | — | |
| SCHEMBL15043613 | 0.61 | MIF (0.51) | MIFITGB3ITGA2BHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |