Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 15/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880311 | 0.87 | TP53 (0.48) | PTPN11MAPTALDH1A1TSHRHTT | |
| SCHEMBL5657836 | 0.80 | HTR1A (0.60) | PTPN11MAPTALDH1A1ADRB2GAA | |
| SCHEMBL5657025 | 0.77 | PTPN11 (0.57) | PTPN11MAPTALDH1A1ADRB2GAA | |
| SCHEMBL2275867 | 0.72 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL12372236 | 0.70 | PTPN11 (0.86) | PTPN11MAPT | |
| SCHEMBL12372359 | 0.70 | PTPN11 (0.87) | PTPN11 | |
| SCHEMBL2275902 | 0.70 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL2275960 | 0.69 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL7644001 | 0.69 | NOTUM (0.67) | PTPN11MAPTALDH1A1ADRB2GAA | |
| SCHEMBL5655729 | 0.68 | PTPN11 (0.58) | PTPN11MAPTALDH1A1ADRB2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074796-B2 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives | H. LUNDBECK A/S (DK) | 2006-07-11 | — | — | US | disclosed |