Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880585 | 0.99 | SLC6A4 (0.61) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL5880606 | 0.99 | SLC6A4 (0.61) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL5880594 | 0.96 | SLC6A4 (0.56) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL150032 | 0.85 | SLC6A4 (0.73) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL28739210 | 0.84 | SLC6A4 (0.64) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL5205111 | 0.84 | SLC6A4 (0.64) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL28739224 | 0.83 | SLC6A4 (0.62) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL28739239 | 0.83 | SLC6A4 (0.62) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL28739230 | 0.83 | SLC6A4 (0.62) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 | |
| SCHEMBL6943206 | 0.83 | SLC6A4 (0.62) | SLC6A4SLC6A2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006523182-A | — | — | 2006-10-12 | — | — | JP | claimed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | claimed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | claimed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | disclosed |