Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 5/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300507 | 0.97 | ALOX5 (0.57) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL29362847 | 0.97 | ALOX5 (0.57) | ALOX5ESR1ESR2KDM4EMEN1 | |
| Biphenyl SCHEMBL27607782 | 0.95 | ALOX5 (0.55) | ALOX5ESR1ESR2KDM4EMEN1 | |
| Lithium SCHEMBL38665532 | 0.95 | ALOX5 (0.55) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL2709851 | 0.93 | ALOX5 (0.59) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL29591632 | 0.93 | ALOX5 (0.59) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL1527283 | 0.93 | ALOX5 (0.53) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL23269791 | 0.91 | ESR1 (0.55) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL30337996 | 0.90 | ESR1 (0.59) | ALOX5ESR1ESR2KDM4EMEN1 | |
| SCHEMBL10864353 | 0.90 | ESR1 (0.59) | ALOX5ESR1ESR2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049011-B2 | Organic electroluminescent device | TDK CORPORATION (JP) | 2006-05-23 | — | — | US | disclosed |
| US-20040048100-A1 | Organic electroluminescent device | TDK CORPORATION (JP) | 2004-03-11 | — | — | US | disclosed |