Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | NMBR | P28336 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RB1 | P06400 | 3/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5881166 | 0.90 | MEN1 (0.37) | TACR1MEN1KMT2AKDM4EHTT | |
| SCHEMBL5881165 | 0.82 | TACR1 (0.52) | TACR1NMBRKDM4ERB1ALDH1A1 | |
| SCHEMBL5881088 | 0.78 | TACR1 (0.66) | TACR1NMBRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5880965 | 0.74 | TACR1 (0.60) | TACR1NMBRMAPT | |
| SCHEMBL5881089 | 0.71 | KDM4E (0.41) | TACR1MEN1KMT2AKDM4EHTT | |
| SCHEMBL5881032 | 0.65 | TACR1 (0.51) | TACR1NMBRMEN1KMT2AKDM4E | |
| SCHEMBL6609382 | 0.63 | TACR1 (0.51) | TACR1NMBRKMT2AKDM4EHSD17B10 | |
| SCHEMBL14003981 | 0.60 | TACR1 (0.52) | TACR1NMBRKMT2AKDM4EHSD17B10 | |
| SCHEMBL11838605 | 0.59 | LMNA (0.47) | TACR1KDM4ECHRNA7ALDH1A1MAPT | |
| SCHEMBL30274452 | 0.58 | PRMT5 (0.56) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122570-B2 | Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) | ZENTARIS AG (DE) | 2006-10-17 | — | — | US | claimed |
| US-7122570-B2 | Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) | ZENTARIS AG (DE) | 2006-10-17 | — | — | US | disclosed |