Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.65 |
| ▸ | PPARA | Q07869 | 4/20 | 0.59 |
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | RARG | P13631 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5883667 | 0.90 | PPARG (0.66) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5884246 | 0.88 | PPARG (0.68) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5883649 | 0.86 | PPARG (0.73) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL13847850 | 0.81 | PPARG (0.72) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5883617 | 0.80 | PPARG (0.75) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5883494 | 0.80 | PPARG (0.69) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5884168 | 0.79 | PPARG (0.74) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL13524844 | 0.79 | PPARG (0.75) | PPARGPPARARXRARARGFFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.79 | PPARG (1.00) | PPARGPPARARXRARARGFFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.79 | PPARG (1.00) | PPARGPPARARXRARARGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001910-B1 | Thiazolidinedione derivatives as antidiabetic agents | VITA-INVEST S.A. (ES) | 2006-02-21 | — | — | US | claimed |
| EP-1231211-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA INVEST SA (ES) | 2003-05-28 | — | — | EP | claimed |
| EP-1231211-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA-INVEST, S.A. (ES) | 2002-08-14 | — | — | EP | claimed |
| US-7001910-B1 | Thiazolidinedione derivatives as antidiabetic agents | VITA-INVEST S.A. (ES) | 2006-02-21 | — | — | US | disclosed |
| EP-1231211-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA INVEST SA (ES) | 2003-05-28 | — | — | EP | disclosed |
| EP-1231211-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA-INVEST, S.A. (ES) | 2002-08-14 | — | — | EP | disclosed |