Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.69 |
| ▸ | PPARA | Q07869 | 3/20 | 0.69 |
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | RARG | P13631 | 1/20 | 0.58 |
| ▸ | MPC2 | O95563 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5884246 | 0.90 | PPARG (0.68) | PPARGPPARARXRARARGMPC2 | |
| SCHEMBL5884045 | 0.87 | PPARG (0.86) | PPARGPPARARXRARARGMPC2 | |
| Lobeglitazone SCHEMBL2742697 | 0.82 | PPARG (1.00) | PPARGPPARARXRARARGMPC2 | |
| Lobeglitazone SCHEMBL20125580 | 0.82 | PPARG (1.00) | PPARGPPARARXRARARGMPC2 | |
| Lobeglitazone SCHEMBL29356140 | 0.82 | PPARG (1.00) | PPARGPPARARXRARARGMPC2 | |
| Lobeglitazone SCHEMBL20125583 | 0.82 | PPARG (1.00) | PPARGPPARARXRARARGMPC2 | |
| SCHEMBL5883667 | 0.80 | PPARG (0.66) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5883617 | 0.80 | PPARG (0.75) | PPARGPPARARXRARARGFFAR1 | |
| SCHEMBL5883194 | 0.80 | PPARG (0.65) | PPARGPPARARXRARARGFFAR1 | |
| Lobeglitazone SCHEMBL29778221 | 0.79 | PPARG (1.00) | PPARGPPARARXRARARGMPC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001910-B1 | Thiazolidinedione derivatives as antidiabetic agents | VITA-INVEST S.A. (ES) | 2006-02-21 | — | — | US | claimed |
| EP-1231211-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA INVEST SA (ES) | 2003-05-28 | — | — | EP | claimed |
| EP-1231211-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA-INVEST, S.A. (ES) | 2002-08-14 | — | — | EP | claimed |
| US-7001910-B1 | Thiazolidinedione derivatives as antidiabetic agents | VITA-INVEST S.A. (ES) | 2006-02-21 | — | — | US | disclosed |
| EP-1231211-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA INVEST SA (ES) | 2003-05-28 | — | — | EP | disclosed |
| EP-1231211-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS | VITA-INVEST, S.A. (ES) | 2002-08-14 | — | — | EP | disclosed |