Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583829 | 0.90 | KDM4E (0.39) | HSD17B10KDM4EDGAT1ALDH1A1MAPT | |
| SCHEMBL2705731 | 0.90 | HSD17B10 (0.36) | HSD17B10KDM4EDGAT1ALDH1A1MAPT | |
| SCHEMBL7882392 | 0.88 | — | — | |
| SCHEMBL595459 | 0.87 | DGAT1 (0.36) | HSD17B10KDM4EDGAT1ALDH1A1MAPT | |
| SCHEMBL10236649 | 0.87 | DGAT1 (0.36) | HSD17B10KDM4EDGAT1ALDH1A1MAPT | |
| SCHEMBL584379 | 0.87 | KDM4E (0.34) | HSD17B10KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL594422 | 0.86 | HSD17B10 (0.39) | HSD17B10KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL594421 | 0.86 | HSD17B10 (0.39) | HSD17B10KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10238476 | 0.85 | CHEK1 (0.32) | — | |
| SCHEMBL584910 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |