Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.69 |
| ▸ | GRM6 | O15303 | 2/20 | 0.69 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.69 |
| ▸ | GSR | P00390 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.69 |
| ▸ | GRM5 | P41594 | 1/20 | 0.69 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.69 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.69 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.69 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.69 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.69 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL5884524 | 1.00 | GRM8 (0.69) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL3659199 | 0.86 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL19348258 | 0.86 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL28753756 | 0.86 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL14742420 | 0.86 | GRM8 (0.86) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16534249 | 0.85 | GSR (0.69) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL27807320 | 0.84 | GRM8 (0.62) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL28980361 | 0.84 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL17127348 | 0.83 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL1330484 | 0.83 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140027-B1 | AQUEOUS SOLUTION FOR COOLING COLD-ROLLED STEEL STRIP IN A CONTINUOUS ANNEALING PROCESS | NIPPON STEEL CORPORATION (JP) | 1989-07-05 | — | — | EP | claimed |
| US-4561911-A | CONTAINING AMINO ACID | NIPPON STEEL CORPORATION (JP) | 1985-12-31 | — | — | US | claimed |
| EP-0140027-A1 | Aqueous solution for cooling cold-rolled steel strip in a continuous annealing process | NIPPON STEEL CORPORATION (JP) | 1985-05-08 | — | — | EP | claimed |
| CN-115792090-B | Method for measuring fatty acid soap content in fatty acyl amino acid salt product | 江南大学 | 2025-01-03 | — | — | CN | disclosed |
| US-7022863-B2 | Production method of pyrrolidone carboxylic acid and salt thereof | AJINOMOTO CO., INC. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20030018202-A1 | Production method of pyrrolidone carboxylic acid and salt thereof | AJINOMOTO CO., INC (JP) | 2003-01-23 | — | — | US | disclosed |
| EP-0140027-B1 | AQUEOUS SOLUTION FOR COOLING COLD-ROLLED STEEL STRIP IN A CONTINUOUS ANNEALING PROCESS | NIPPON STEEL CORPORATION (JP) | 1989-07-05 | — | — | EP | disclosed |