Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 5/20 | 0.47 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.47 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.43 |
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5884692 | 1.00 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5885477 | 1.00 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7598225 | 0.97 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7425620 | 0.93 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7437548 | 0.93 | NOTCH1 (0.42) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7484324 | 0.91 | PSEN1 (0.44) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4982216 | 0.88 | NOTCH1 (0.46) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7426811 | 0.84 | NOTCH1 (0.38) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7427826 | 0.82 | NOTCH1 (0.45) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL6385267 | 0.81 | NOTCH1 (0.39) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112583-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-09-26 | — | — | US | disclosed |