Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 9/20 | 0.47 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
| ▸ | NOTCH3 | Q9UM47 | 6/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5885477 | 0.93 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5884692 | 0.93 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5884699 | 0.93 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7484324 | 0.91 | PSEN1 (0.44) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7598225 | 0.91 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7427826 | 0.89 | NOTCH1 (0.45) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL6385267 | 0.88 | NOTCH1 (0.39) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7437548 | 0.86 | NOTCH1 (0.42) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4982216 | 0.81 | NOTCH1 (0.46) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL7426811 | 0.81 | NOTCH1 (0.38) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | claimed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | claimed |
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |