Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.55 |
| ▸ | AURKA | O14965 | 5/20 | 0.48 |
| ▸ | GRK6 | P43250 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | GRK4 | P32298 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.48 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 11/20 | 0.47 |
| ▸ | JAK2 | O60674 | 11/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589536 | 0.93 | NTRK1 (0.62) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589535 | 0.93 | NTRK1 (0.62) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589089 | 0.90 | NTRK1 (0.65) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589107 | 0.84 | NTRK1 (0.77) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589106 | 0.84 | NTRK1 (0.77) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589432 | 0.84 | NTRK1 (0.76) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL589431 | 0.84 | NTRK1 (0.76) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL588783 | 0.82 | JAK3 (0.57) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL588554 | 0.82 | NTRK1 (0.60) | NTRK1AURKAGRK6IGF1RGRK4 | |
| SCHEMBL588553 | 0.82 | NTRK1 (0.60) | NTRK1AURKAGRK6IGF1RGRK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | claimed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA R&D (SE) | 2010-08-19 | — | — | US | disclosed |
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ABL1, FLT3, ERBB2 | NTRK1 574/4885AURKA 156/4885GRK6 291/4885 |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ABL1, FLT3, ERBB2 | NTRK1 574/4885AURKA 156/4885GRK6 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.