Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.62 |
| ▸ | JAK3 | P52333 | 7/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | IGF1R | P08069 | 4/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589535 | 1.00 | NTRK1 (0.62) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL588638 | 0.93 | NTRK1 (0.55) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589432 | 0.90 | NTRK1 (0.76) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589431 | 0.90 | NTRK1 (0.76) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589107 | 0.89 | NTRK1 (0.77) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589106 | 0.89 | NTRK1 (0.77) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL588554 | 0.87 | NTRK1 (0.60) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL588553 | 0.87 | NTRK1 (0.60) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589659 | 0.85 | NTRK1 (0.56) | NTRK1JAK3AURKAJAK2IGF1R | |
| SCHEMBL589089 | 0.84 | NTRK1 (0.65) | NTRK1JAK3AURKAJAK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | claimed |