Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 13/20 | 0.56 |
| ▸ | ESR1 | P03372 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148273 | 0.97 | ESR2 (0.60) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL781509 | 0.93 | HDAC1 (0.54) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6275125 | 0.90 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL28584923 | 0.90 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL15260520 | 0.90 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL5147779 | 0.90 | ESR2 (0.54) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL42782 | 0.90 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL5146632 | 0.87 | ESR2 (0.52) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25253951 | 0.86 | ESR2 (0.47) | ESR2ESR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL435619 | 0.86 | HTR3A (0.59) | ESR2ESR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138554-B2 | Synthesis of (dibromocyclobuta) aromatic compounds | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION (IL) | 2006-11-21 | — | — | US | disclosed |
| JP-2005132735-A | POLYFUNCTIONAL CYCLOBUTABENZENE AND METHOD FOR PRODUCING THE SAME | JAPAN SCIENCE & TECHNOLOGY AGENCY | 2005-05-26 | — | — | JP | disclosed |
| US-20040116755-A1 | Synthesis of (Dibromocyclobuta) aromatic compounds | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION (IL) | 2004-06-17 | — | — | US | disclosed |
| WO-2002102810-A2 | SYNTHESIS OF (DIBROMOCYCLOBUTA) AROMATIC COMPOUNDS | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2002-12-27 | — | — | WO | disclosed |
| US-5770763-A | POLYARYLCYCLOBUTENES DERIVED FROM 3,6 FUNCTIONALIZED MONO AND DICYCLOBUTABENZENE | THE BOARD OF REGENTS OF THE UNIV. OF MICHIGAN (US) | 1998-06-23 | — | — | US | disclosed |
| US-5552508-A | Difunctional bitricyclodecatriene monomers | UNIVERSITY OF MICHIGAN, THE BOARD OF REGENTS (US) | 1996-09-03 | — | — | US | disclosed |