Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 11/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146632 | 0.97 | ESR2 (0.52) | ESR2HDAC1HDAC8HDAC6ESR1 | |
| SCHEMBL781509 | 0.97 | HDAC1 (0.54) | ESR2HDAC1HDAC8HDAC6ESR1 | |
| SCHEMBL28584923 | 0.93 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL5148273 | 0.93 | ESR2 (0.60) | ESR2HDAC1HDAC8HDAC6ESR1 | |
| SCHEMBL42782 | 0.93 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL15260520 | 0.93 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL6275125 | 0.93 | HDAC8 (0.52) | ESR2HDAC1HDAC8HDAC6NOTUM | |
| SCHEMBL5886587 | 0.90 | ESR2 (0.56) | ESR2HDAC1HDAC8HDAC6ESR1 | |
| SCHEMBL2884020 | 0.89 | ESR2 (0.57) | ESR2ESR1CYP3A4CYP2C9CYP2D6 | |
| Hydrogen Peroxide SCHEMBL11391495 | 0.88 | HAO1 (0.55) | ESR2HDAC1HDAC8HDAC6NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299072-A1 | KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299072-A1 | KV1.5 POTASSIUM CHANNEL INHIBITORS | KCNA5, KCNH1, KCNK5 | ESR2 4173/4885HDAC1 390/4885HDAC8 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.