Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 15/20 | 0.67 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | MMP10 | P09238 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.43 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888987 | 0.89 | APP (0.68) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL4193946 | 0.81 | APP (0.49) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4193945 | 0.81 | APP (0.49) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4484575 | 0.80 | APP (0.67) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL13875783 | 0.80 | APP (0.48) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4478799 | 0.79 | APP (0.67) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL5086527 | 0.79 | APP (0.64) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL4492146 | 0.78 | APP (0.66) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL4499107 | 0.78 | PSEN1 (0.61) | APPNPY1RPSEN1PSEN2APH1B | |
| SCHEMBL4487846 | 0.77 | PSEN1 (0.62) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112583-B2 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-09-26 | — | — | US | disclosed |