Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 5/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5890422 | 0.99 | CDK4 (0.46) | EIF2AK2CDK4CCNA2CDK2CDK1 | |
| SCHEMBL5890976 | 0.99 | CDK4 (0.46) | EIF2AK2CDK4CCNA2CDK2CDK1 | |
| SCHEMBL5890757 | 0.92 | ADORA1 (0.48) | EIF2AK2CDK4CCNA2CDK2IKBKB | |
| SCHEMBL6107098 | 0.91 | CDK4 (0.50) | EIF2AK2CDK4CCNA2CDK2CDK1 | |
| SCHEMBL6106143 | 0.88 | CDK4 (0.48) | EIF2AK2CDK4CCNA2CDK2CDK1 | |
| SCHEMBL6106438 | 0.85 | ADORA1 (0.48) | EIF2AK2CDK4CCNA2CDK2IKBKB | |
| SCHEMBL6105068 | 0.85 | CDK4 (0.46) | EIF2AK2CDK4CCNA2CDK2CDK1 | |
| SCHEMBL6106109 | 0.85 | ADORA1 (0.48) | EIF2AK2CDK4CCNA2CDK2IKBKB | |
| SCHEMBL5890674 | 0.85 | EIF2AK2 (0.44) | EIF2AK2CDK4CCNA2CDK2IKBKB | |
| SCHEMBL5891079 | 0.85 | CSNK1D (0.50) | EIF2AK2CDK4IKBKBMAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962914-B2 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-08 | — | — | US | claimed |
| EP-1385847-B1 | PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORP (US) | 2005-06-01 | — | — | EP | claimed |
| US-20040142941-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2004-07-22 | — | — | US | claimed |
| US-7030134-B2 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-18 | — | — | US | disclosed |
| US-6962914-B2 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-08 | — | — | US | disclosed |
| US-20050192303-A1 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | GUDMUNDSSON KRISTJAN (US) | 2005-09-01 | — | — | US | disclosed |
| EP-1385847-B1 | PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORP (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20040142941-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142941-A1 | Therapeutic compounds | PCSK9, ABCB1, ABCB11 | EIF2AK2 3551/4885CDK4 2345/4885CCNA2 2852/4885 |
| US-20050192303-A1 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds | DPYD, TYMP, P2RY4 | EIF2AK2 1588/4885CDK4 115/4885CCNA2 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.