Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PRKX | P51817 | 2/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5891323 | 1.00 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AEGFR | |
| SCHEMBL5891322 | 1.00 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2AEGFR | |
| SCHEMBL2358959 | 0.79 | KDM4E (0.49) | KDM4EMEN1MAPTKMT2AEGFR | |
| SCHEMBL2310615 | 0.79 | KDM4E (0.49) | KDM4EMEN1MAPTKMT2AEGFR | |
| SCHEMBL2309935 | 0.79 | KDM4E (0.49) | KDM4EMEN1MAPTKMT2AEGFR | |
| SCHEMBL5891543 | 0.75 | ITGB1 (0.51) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL5891538 | 0.75 | ITGB1 (0.51) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL15636352 | 0.73 | MAPT (0.45) | KDM4EMEN1MAPTKMT2AIRAK4 | |
| SCHEMBL12165799 | 0.73 | KDM4E (0.59) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL30431564 | 0.72 | RAB9A (0.47) | KDM4EMEN1MAPTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060046992-A1 | HETEROBICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-03-02 | — | — | US | disclosed |
| EP-1533312-A1 | HETERO-BICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046992-A1 | HETEROBICYCLIC COMPOUNDS | ARL1, ARRB1, ATXN2L | KDM4E 2316/4885MEN1 2834/4885MAPT 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.