Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.54 |
| ▸ | INSR | P06213 | 18/20 | 0.54 |
| ▸ | IGF1R | P08069 | 10/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 2/20 | 0.49 |
| ▸ | ROS1 | P08922 | 2/20 | 0.49 |
| ▸ | FER | P16591 | 2/20 | 0.49 |
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | FRK | P42685 | 2/20 | 0.49 |
| ▸ | MST1R | Q04912 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL590620 | 0.95 | ALK (0.58) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL590062 | 0.94 | ALK (0.54) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL591974 | 0.91 | ALK (0.58) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL590076 | 0.88 | ALK (0.56) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL590126 | 0.87 | IGF1R (0.62) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL590964 | 0.87 | ALK (0.54) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL589685 | 0.87 | ALK (0.54) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL592563 | 0.87 | ALK (0.57) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL591336 | 0.87 | INSR (0.55) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL592510 | 0.87 | ALK (0.58) | ALKINSRIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114865-B2 | Indazole derivatives as kinase inhibitors for the treatment of cancer | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-14 | — | — | US | disclosed |