Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.49 |
| ▸ | PAK3 | O75914 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 4/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220866 | 0.87 | JAK2 (0.61) | JAK2NTRK1JAK3 | |
| SCHEMBL589564 | 0.85 | NTRK1 (0.63) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL4162039 | 0.85 | NTRK1 (0.62) | JAK2NTRK1IGF1RJAK3 | |
| SCHEMBL15091280 | 0.83 | PAK1 (0.64) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL589514 | 0.82 | NTRK1 (0.51) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL4144541 | 0.81 | NTRK1 (0.59) | JAK2NTRK1IGF1R | |
| SCHEMBL4070836 | 0.78 | JAK2 (0.40) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL15058643 | 0.78 | PAK1 (0.47) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL22535639 | 0.77 | JAK2 (0.58) | JAK2NTRK1PAK3PAK1PAK2 | |
| SCHEMBL14722563 | 0.77 | IGF1R (0.40) | IGF1RMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | claimed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |