Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.42 |
| ▸ | PAK3 | O75914 | 4/20 | 0.42 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589564 | 0.88 | NTRK1 (0.63) | NTRK1JAK2PAK1PAK3PAK2 | |
| SCHEMBL4162039 | 0.84 | NTRK1 (0.62) | NTRK1JAK2IGF1RJAK3 | |
| SCHEMBL15059617 | 0.83 | PAK1 (0.62) | NTRK1PAK1PAK3PAK2IGF1R | |
| SCHEMBL15059652 | 0.83 | PAK1 (0.62) | NTRK1PAK1PAK3PAK2IGF1R | |
| SCHEMBL220866 | 0.83 | JAK2 (0.61) | NTRK1JAK2JAK3 | |
| SCHEMBL589443 | 0.82 | JAK2 (0.52) | NTRK1JAK2PAK1PAK3PAK2 | |
| SCHEMBL4144541 | 0.82 | NTRK1 (0.59) | NTRK1JAK2IGF1R | |
| SCHEMBL15059009 | 0.80 | PAK1 (0.63) | NTRK1JAK2PAK1PAK3PAK2 | |
| SCHEMBL15091280 | 0.79 | PAK1 (0.64) | NTRK1JAK2PAK1PAK3PAK2 | |
| SCHEMBL4070836 | 0.77 | JAK2 (0.40) | NTRK1JAK2PAK1PAK3PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | claimed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |