Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | PGK1 | P00558 | 3/20 | 0.43 |
| ▸ | PGK2 | P07205 | 3/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589504 | 1.00 | ADORA2A (0.59) | ADORA2AADORA3ADORA1PGK1PGK2 | |
| SCHEMBL590983 | 0.89 | ADORA2A (0.60) | ADORA2AADORA3ADORA1PGK1PGK2 | |
| SCHEMBL592302 | 0.87 | ADORA2A (0.69) | ADORA2AADORA3ADORA1 | |
| SCHEMBL592303 | 0.87 | ADORA2A (0.69) | ADORA2AADORA3ADORA1 | |
| SCHEMBL590768 | 0.85 | ADORA2A (0.54) | ADORA2AADORA3ADORA1CDK2 | |
| SCHEMBL590767 | 0.85 | ADORA2A (0.54) | ADORA2AADORA3ADORA1CDK2 | |
| SCHEMBL588981 | 0.83 | ADORA2A (0.78) | ADORA2AADORA3ADORA1PGK1PGK2 | |
| SCHEMBL591697 | 0.83 | ADORA2A (0.61) | ADORA2AADORA3ADORA1PGK1PGK2 | |
| SCHEMBL589415 | 0.82 | ADORA2A (0.85) | ADORA2AADORA3ADORA1PGK1PGK2 | |
| SCHEMBL589515 | 0.81 | ADORA2A (0.73) | ADORA2AADORA3ADORA1PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114877-B2 | Antiinflammatory agnets; chronic obstructive pulmonary diseases | NOVARTIS AG (CH) | 2012-02-14 | — | — | US | disclosed |
| EP-2012759-B1 | PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2010-03-10 | — | — | EP | disclosed |
| US-20090093633-A1 | Organic Compounds | NOVARTIS AG | 2009-04-09 | — | — | US | disclosed |
| EP-1841768-B1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| US-20080207648-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093633-A1 | Organic Compounds | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA1 3/4885 |
| US-20080207648-A1 | Organic Compounds | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.