Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543469 | 0.93 | USP2 (0.40) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL27129217 | 0.88 | USP2 (0.44) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL5896048 | 0.86 | NPC1 (0.34) | SMN1; SMN2RECQL | |
| SCHEMBL15076445 | 0.85 | USP2 (0.43) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL25275634 | 0.84 | USP2 (0.47) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL21856259 | 0.84 | USP2 (0.42) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL5895758 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL15076439 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL5896294 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2RECQLHPGDACACB | |
| SCHEMBL3164042 | 0.81 | USP2 (0.46) | USP2SMN1; SMN2RECQLHPGDNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091211-B2 | Cyclopentyl modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | CCR5, CXCR1, ACKR3 | USP2 4590/4885SMN1; SMN2 4725/4885RECQL 755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.