Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 7/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 7/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897126 | 0.86 | MAPK14 (0.52) | MEN1KMT2AL3MBTL1RAB9AKCNQ3 | |
| SCHEMBL6477268 | 0.83 | MAPK14 (0.61) | MEN1KMT2ARAB9AMAPTMAPK14 | |
| SCHEMBL6484987 | 0.81 | NPC1 (0.51) | MEN1KMT2ARAB9ASMN1; SMN2MAPT | |
| SCHEMBL5215873 | 0.80 | BRAF (0.63) | CYP2C9 | |
| SCHEMBL2303285 | 0.80 | KCNQ3 (0.80) | MEN1KMT2ARAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL2306227 | 0.79 | RAB9A (0.67) | MEN1KMT2AL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL404209 | 0.78 | SMN1; SMN2 (0.74) | MEN1KMT2ARAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL6485161 | 0.78 | MAPK14 (0.67) | MEN1KMT2ARAB9AMAPTMAPK14 | |
| SCHEMBL5897160 | 0.78 | MAPK14 (0.70) | MEN1KMT2ARAB9ASMN1; SMN2KCNQ3 | |
| SCHEMBL18109908 | 0.78 | HSF1 (0.67) | MEN1KMT2ARAB9ASMN1; SMN2KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |