Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.61 |
| ▸ | BRAF | P15056 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | SMO | Q99835 | 2/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897487 | 0.84 | CSF1R (0.81) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL6484862 | 0.79 | MAPK14 (0.85) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL6477991 | 0.78 | MAPK14 (0.76) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL5007830 | 0.78 | MAPK14 (0.72) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL6477729 | 0.78 | MAPK14 (0.74) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL2978412 | 0.77 | CSF1R (0.70) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL10028403 | 0.77 | MAPK14 (0.85) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL6477982 | 0.77 | MAPK14 (0.70) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL6781525 | 0.76 | MAPK14 (0.83) | MAPK14BRAFKDM4EALDH1A1MAPT | |
| SCHEMBL1424183 | 0.76 | MAPK14 (1.00) | MAPK14BRAFKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060700-B2 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2006-06-13 | — | — | US | disclosed |
| US-20030105142-A1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB | 2003-06-05 | — | — | US | disclosed |
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105142-A1 | Amide derivatives useful as inhibitors of the production of cytokines | IL6, IL6ST, IL2 | MAPK14 2563/4885BRAF 1764/4885KDM4E 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.