Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897448 | 1.00 | ITGB1 (0.58) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5897439 | 1.00 | ITGB1 (0.58) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5896851 | 0.90 | SPHK2 (0.52) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5896862 | 0.90 | SPHK2 (0.52) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5896858 | 0.90 | SPHK2 (0.52) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5895826 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5895014 | 0.89 | SPHK2 (0.49) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5895029 | 0.89 | SPHK2 (0.49) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5895038 | 0.89 | SPHK2 (0.49) | ITGB1ITGA4KDM4ESPHK2SPHK1 | |
| SCHEMBL5895809 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4KDM4ESPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041690-B2 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY, LLC (US) | 2006-05-09 | — | — | US | disclosed |
| US-20060004063-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY, LLC | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004063-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, EIF5B, POLI | ITGB1 3606/4885ITGA4 4280/4885KDM4E 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.