Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.84 |
| ▸ | NPC1 | O15118 | 8/20 | 0.80 |
| ▸ | RAB9A | P51151 | 8/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16286465 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL28191183 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL12162667 | 0.79 | SMN1; SMN2 (0.76) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL22607068 | 0.78 | RAB9A (0.53) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL27607298 | 0.78 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL17632657 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL31166686 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL7469771 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9APOLBTDP1 | |
| SCHEMBL17935034 | 0.76 | HTT (0.62) | SMN1; SMN2NPC1LMNAHTTKMT2A | |
| SCHEMBL7679736 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125883-B1 | Integrin receptor ligands | ABBOTT GMBH & CO. KG (DE) | 2006-10-24 | — | — | US | disclosed |
| EP-1171435-A2 | PYRIMIDINE-2-ONE DERIVATIVES AS INTEGRIN RECEPTOR LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061551-A2 | PYRIMIDINE-2-ONE DERIVATIVES AS INTEGRIN RECEPTOR LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-19 | — | — | WO | disclosed |