Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | NPC1 | O15118 | 5/20 | 0.79 |
| ▸ | RAB9A | P51151 | 5/20 | 0.79 |
| ▸ | PKM | P14618 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.70 |
| ▸ | RELA | Q04206 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | COMT | P21964 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2242715 | 0.89 | NPC1 (1.00) | KDM4EALDH1A1NPC1RAB9APKM | |
| Hydrochloric Acid SCHEMBL28150094 | 0.87 | NPC1 (0.97) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL5897634 | 0.85 | CHEK2 (0.68) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL5634840 | 0.85 | NPC1 (0.91) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL3572190 | 0.84 | CHEK2 (0.71) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL13015025 | 0.83 | NPC1 (0.88) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL6530157 | 0.83 | HPSE (0.77) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL1378713 | 0.83 | CHEK2 (0.83) | CHEK2 | |
| SCHEMBL2617471 | 0.82 | NPC1 (1.00) | KDM4EALDH1A1NPC1RAB9APKM | |
| SCHEMBL3918718 | 0.81 | NPC1 (0.83) | KDM4EALDH1A1NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |