Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.91 |
| ▸ | RAB9A | P51151 | 7/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.91 |
| ▸ | PKM | P14618 | 3/20 | 0.91 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | GUSB | P08236 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13015025 | 0.98 | NPC1 (0.88) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2242715 | 0.95 | NPC1 (1.00) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28150094 | 0.94 | NPC1 (0.97) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3417342 | 0.92 | KDM4E (0.76) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3335320 | 0.89 | KDM4E (0.71) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3918718 | 0.87 | NPC1 (0.83) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3919844 | 0.86 | KDM4E (0.68) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2248110 | 0.85 | SMN1; SMN2 (0.82) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3367497 | 0.85 | KDM4E (0.82) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL28256337 | 0.85 | NPC1 (0.66) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | claimed |
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | disclosed |