Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.57 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086452 | 0.88 | CHEK2 (0.62) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3566995 | 0.87 | CHEK2 (0.67) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3559959 | 0.86 | CHEK2 (0.83) | CHEK2 | |
| SCHEMBL5680606 | 0.86 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5897720 | 0.84 | CHEK2 (0.74) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL5177946 | 0.81 | CHEK2 (0.66) | CHEK2KMT2A | |
| SCHEMBL11331533 | 0.80 | KDM4E (0.73) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL5897634 | 0.80 | CHEK2 (0.68) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL1664216 | 0.79 | KDM4E (0.97) | CHEK2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3663760 | 0.77 | KDM4E (0.73) | CHEK2KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132440-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-11-07 | — | — | US | disclosed |