Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 11/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalamide SCHEMBL2641517 | 0.95 | CHEK2 (0.76) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL5634526 | 0.92 | CHEK2 (0.77) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL1664216 | 0.86 | KDM4E (0.97) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL6527951 | 0.85 | HPSE (0.61) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL11331533 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL21018500 | 0.84 | CHEK2 (0.63) | CHEK2 | |
| SCHEMBL3340887 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL17393252 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL17393254 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1HPGDKMT2ACHEK2 | |
| SCHEMBL29386825 | 0.83 | NPC1 (0.88) | KDM4EALDH1A1HPGDKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299413-A | A method of no metal catalytic prepares 2- (aminocarbonyl phenyl) benzoxazoles and its derivative | 复旦大学 | 2018-07-20 | — | — | CN | disclosed |
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |