Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.54 |
| ▸ | TEK | Q02763 | 11/20 | 0.54 |
| ▸ | BRAF | P15056 | 6/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899329 | 0.88 | KDR (0.66) | KDRTEKBRAFRAF1 | |
| SCHEMBL5899287 | 0.86 | KDR (0.55) | KDRTEKBRAFRAF1 | |
| SCHEMBL5899290 | 0.83 | KDR (0.61) | KDRTEKBRAFRAF1 | |
| SCHEMBL5899312 | 0.78 | RAF1 (0.63) | KDRTEKBRAFRAF1 | |
| SCHEMBL14375384 | 0.74 | KDR (0.78) | KDRTEKRAF1 | |
| SCHEMBL5899314 | 0.74 | KDR (0.67) | KDRTEKBRAFRAF1 | |
| SCHEMBL5899257 | 0.72 | BRAF (0.58) | KDRTEKBRAFRAF1 | |
| SCHEMBL5899280 | 0.72 | KDR (0.44) | KDRTEKBRAFRAF1 | |
| SCHEMBL19888735 | 0.72 | KDR (0.63) | KDRTEKBRAFRAF1 | |
| SCHEMBL14375374 | 0.71 | KDR (0.78) | KDRTEKBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | US | claimed |
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | TIE1, UCK2, UTS2R | KDR 45/4885TEK 203/4885BRAF 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.