Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.68 |
| ▸ | TEK | Q02763 | 17/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899307 | 0.92 | KDR (0.65) | KDRTEKRAF1 | |
| SCHEMBL5341416 | 0.80 | KDR (0.68) | KDRTEKRAF1 | |
| SCHEMBL937617 | 0.80 | KDR (0.69) | KDRTEKRAF1 | |
| SCHEMBL5346580 | 0.80 | TEK (0.77) | KDRTEKRAF1 | |
| SCHEMBL22803985 | 0.80 | ESR1 (0.56) | KDRTEK | |
| SCHEMBL5345019 | 0.79 | KDR (0.86) | KDRTEKRAF1 | |
| SCHEMBL31504025 | 0.79 | KDR (0.64) | KDRTEKRAF1 | |
| SCHEMBL5899276 | 0.79 | KDR (0.58) | KDRTEKRAF1 | |
| SCHEMBL5899249 | 0.79 | KDR (0.60) | KDRTEKRAF1 | |
| SCHEMBL31504015 | 0.78 | KDM4E (0.62) | KDRTEKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | US | claimed |
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241301-A1 | Urea derivatives and their use as tyrosinkinase inhibitors | TIE1, UCK2, UTS2R | KDR 45/4885TEK 203/4885RAF1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.