Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.41 |
| ▸ | CTSS | P25774 | 7/20 | 0.38 |
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSB | P07858 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895283 | 0.95 | CTSL (0.39) | CTSLCTSSCTSKCTSBJAK2 | |
| SCHEMBL3898963 | 0.92 | CTSL (0.43) | CTSLCTSSCTSKCTSBALDH1A1 | |
| SCHEMBL3896939 | 0.91 | CTSL (0.42) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3898205 | 0.88 | CTSL (0.45) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3894998 | 0.87 | CTSL (0.46) | CTSLCTSSCTSKCTSBALDH1A1 | |
| SCHEMBL3900293 | 0.87 | CTSL (0.44) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3903294 | 0.86 | CTSL (0.46) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3899281 | 0.85 | CTSL (0.43) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7482961 | 0.85 | CTSL (0.49) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3910469 | 0.85 | CTSL (0.42) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982263-B2 | Nitriles useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-01-03 | — | — | US | claimed |