Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 16/20 | 0.55 |
| ▸ | CDK4 | P11802 | 11/20 | 0.55 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 11/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 2/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | RB1 | P06400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554036 | 0.91 | CTSS (0.50) | CCND1CDK4CTSKCTSSCDK2 | |
| SCHEMBL5900564 | 0.87 | CCND1 (0.46) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL4835890 | 0.86 | CCND1 (0.56) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL5900474 | 0.84 | CCND1 (0.65) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL4830686 | 0.84 | CDK2 (0.47) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL5900336 | 0.83 | PIK3CA (0.48) | CCND1CDK4MEN1KMT2AATM | |
| SCHEMBL5900431 | 0.83 | CYP1A2 (0.56) | CCND1CDK4CTSKCTSSCDK2 | |
| SCHEMBL5900383 | 0.83 | CDK2 (0.59) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL29593898 | 0.83 | CDK2 (0.59) | CCND1CDK4CDK2CCNA2CCNE1 | |
| SCHEMBL4833613 | 0.82 | CCND1 (0.43) | CCND1CDK4CDK2CCNA2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889696-B2 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-25 | — | — | US | disclosed |
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | PFIZER INC | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269831-A1 | SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF | MKI67, CCNA1, FOLR1 | CCND1 90/4885CDK4 86/4885CTSK 3952/4885 |
| US-20060142312-A1 | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones | CDK4, CDK2, CCNA1 | CCND1 9/4885CDK4 1/4885CTSK 2472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.