Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.59 |
| ▸ | PDE1A | P54750 | 5/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.59 |
| ▸ | PDE6A | P16499 | 3/20 | 0.44 |
| ▸ | PDE6D | O43924 | 2/20 | 0.44 |
| ▸ | PDE6G | P18545 | 2/20 | 0.44 |
| ▸ | PDE6B | P35913 | 2/20 | 0.44 |
| ▸ | PDE6C | P51160 | 2/20 | 0.44 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5901354 | 0.94 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5901816 | 0.92 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5901924 | 0.92 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6502812 | 0.90 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5902123 | 0.90 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5901717 | 0.90 | PDE5A (0.58) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6479365 | 0.90 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5902447 | 0.89 | PDE5A (0.57) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL6332319 | 0.89 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CPDE6A | |
| SCHEMBL5901879 | 0.89 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098207-B2 | Imidazotriazinones and the use thereof | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050267112-A1 | Novel imidazotriazinones and the use thereof | BAYER AKTIENGESELLSCHAFT (US) | 2005-12-01 | — | — | US | disclosed |
| EP-1280805-A1 | NOVEL IMIDAZOTRIAZINONES AND THE USE THEREOF | Bayer Aktiengesellschaft (DE) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001064677-A1 | NOVEL IMIDAZOTRIAZINONES AND THE USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267112-A1 | Novel imidazotriazinones and the use thereof | CYP3A7, CYP4F2, CYP4F3 | PDE5A 338/4885PDE1A 376/4885PDE1B 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.