Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 11/20 | 0.59 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58645 | 0.90 | ACVRL1 (0.61) | ACVRL1MERTKFGFR1PIK3CDRET | |
| SCHEMBL2635793 | 0.82 | ACVRL1 (0.64) | ACVRL1MERTKRIPK1FGFR1FGFR3 | |
| SCHEMBL60504 | 0.82 | ACVRL1 (0.69) | ACVRL1MERTKFGFR1FGFR3PIK3CD | |
| SCHEMBL65771 | 0.81 | ACVRL1 (0.58) | ACVRL1MERTKRIPK1FGFR1PIK3CD | |
| SCHEMBL5132591 | 0.81 | ACVRL1 (0.52) | ACVRL1MERTKRIPK1FGFR1PIK3CD | |
| SCHEMBL58580 | 0.80 | ACVRL1 (0.50) | ACVRL1MERTKPIK3CD | |
| SCHEMBL5179824 | 0.79 | ACVRL1 (0.51) | ACVRL1MERTKRIPK1FGFR1PIK3CD | |
| SCHEMBL5132559 | 0.79 | ACVRL1 (0.51) | ACVRL1MERTKRIPK1FGFR1PIK3CD | |
| SCHEMBL16011216 | 0.77 | ACVRL1 (0.65) | ACVRL1MERTKRIPK1FGFR1RET | |
| SCHEMBL58415 | 0.76 | ACVRL1 (0.52) | ACVRL1MERTKRIPK1FGFR1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |