Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 16/20 | 0.68 |
| ▸ | TACR2 | P21452 | 15/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909008 | 1.00 | TACR3 (0.68) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL5420737 | 0.89 | TACR3 (0.71) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL5448622 | 0.89 | TACR3 (0.61) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL1581445 | 0.85 | TACR3 (0.69) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL1581136 | 0.85 | TACR3 (0.66) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL8268049 | 0.85 | TACR3 (0.68) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL1581261 | 0.85 | TACR3 (0.68) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL5425877 | 0.84 | CYP2C9 (0.75) | TACR3TACR2OPRM1CYP2C9 | |
| SCHEMBL1581440 | 0.84 | TACR3 (0.67) | TACR3TACR2OPRM1CYP2C9TRPV4 | |
| SCHEMBL1580919 | 0.84 | TACR3 (0.67) | TACR3TACR2OPRM1CYP2C9TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060223819-A1 | Quinoline Derivatives as NK-3 Antagonists | GlaxoSmithKline S.P.A. & Laboratoire | 2006-10-05 | — | — | US | disclosed |
| US-20040097518-A1 | Quinoline derivatives as nk-3 antagonists | GLAXOSMITHKLINE S.P.A. (IT) | 2004-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223819-A1 | Quinoline Derivatives as NK-3 Antagonists | KCNK3, KCNQ3, KCNN3 | TACR3 50/4885TACR2 83/4885OPRM1 1266/4885 |
| US-20040097518-A1 | Quinoline derivatives as nk-3 antagonists | KCNK3, KCNQ3, KCNN3 | TACR3 53/4885TACR2 83/4885OPRM1 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.