SCHEMBL5927342

SCHEMBL5927342

O=C(O)CC(NC(=O)c1cc(Cl)ccc1N(CCCc1ccccc1)C(=O)c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ UTS2R Q9UKP6 11/20 0.46
▸ CTSA P10619 3/20 0.44
▸ CYP26A1 O43174 2/20 0.44
▸ SUCNR1 Q9BXA5 2/20 0.42
▸ THRB P10828 1/20 0.41
▸ PTGIR P43119 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5926685 0.91 CTSA (0.44) UTS2RCTSACYP26A1SUCNR1THRB
SCHEMBL5926540 0.87 CTSA (0.47) UTS2RCTSACYP26A1SUCNR1
SCHEMBL5927336 0.86 ITGB1 (0.47) —
SCHEMBL5926437 0.84 CYP26A1 (0.47) UTS2RCTSACYP26A1SUCNR1
SCHEMBL5926678 0.83 CYP26A1 (0.48) UTS2RCTSACYP26A1
SCHEMBL5926872 0.83 ADAMTS5 (0.44) UTS2RCTSACYP26A1SUCNR1THRB
SCHEMBL5927525 0.80 KMT2A (0.52) UTS2RCTSACYP26A1
SCHEMBL5927193 0.79 CTSA (0.48) UTS2RCTSACYP26A1SUCNR1
SCHEMBL5926624 0.79 CYP26A1 (0.46) UTS2RCTSACYP26A1
SCHEMBL5926684 0.77 ITGB1 (0.47) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060276518-A1 Aryl and heteroaryl compounds and methods to modulate coagulation TRANSTECH PHARMA, INC. 2006-12-07 — — US disclosed
US-7122580-B2 Aryl and heteroaryl compounds and methods to modulate coagulation TRANSTECH PHARMA, INC. (US) 2006-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276518-A1 Aryl and heteroaryl compounds and methods to modulate coagulation TFPI, F9, F2 UTS2R 2544/4885CTSA 426/4885CYP26A1 526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback