Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | LTA4H | P09960 | 3/20 | 0.59 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL4305051 | 0.86 | GSR (0.57) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL941017 | 0.86 | GSR (0.57) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL9716604 | 0.86 | GSR (0.57) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL28214073 | 0.86 | GSR (0.91) | GSRMMP2POLBKMT2ATDP1 | |
| Lysine SCHEMBL28249818 | 0.85 | GSR (0.69) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL28249816 | 0.85 | GSR (0.69) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL20303616 | 0.84 | GSR (0.54) | GSRLTA4HMMP2POLBKMT2A | |
| Lysine SCHEMBL20303617 | 0.84 | GSR (0.54) | GSRLTA4HMMP2POLBKMT2A | |
| Aminodiphenylmethane SCHEMBL23925166 | 0.83 | GSR (0.67) | GSRMMP2POLBKMT2ATDP1 | |
| Lysine SCHEMBL3907035 | 0.83 | GSR (0.67) | GSRLTA4HMMP2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703167-B2 | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2014-04-22 | — | — | US | claimed |
| WO-2007146001-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES FOR CONTROLLED RELEASE OF A HYDROPHILIC DRUG AND A HYDROPHOBIC DRUG | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2007-12-21 | — | — | WO | claimed |
| US-20070280991-A1 | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2007-12-06 | — | — | US | claimed |
| EP-1848470-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | Abbott Cardiovascular Systems, Inc. (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2007097887-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2007-08-30 | — | — | WO | claimed |
| US-20070003589-A1 | Coatings for implantable medical devices containing attractants for endothelial cells | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2007-01-04 | — | — | US | claimed |
| WO-2006112932-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2006-10-26 | — | — | WO | claimed |
| US-8703167-B2 | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120135131-A1 | RGD PEPTIDE ATTACHED TO BIOABSORBABLE STENTS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
| US-8118863-B2 | RGD peptide attached to bioabsorbable stents | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2012-02-21 | — | — | US | disclosed |
| US-8114150-B2 | RGD peptide attached to bioabsorbable stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8062350-B2 | RGD peptide attached to bioabsorbable stents | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-7887572-B2 | An implantable device having a bioactive pattern of pores loaded with protein of fibronectin, laminin 5, elastin, silk elastin, or collagen bonded by a spacer to an endothelialization promoter to form a biological conjugate; tissue engineering; stents; heart valves; vascular systems; drug delivery | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2011-02-15 | — | — | US | disclosed |
| US-20070293941-A1 | RGD peptide attached to bioabsorbable stents | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070280991-A1 | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2007-12-06 | — | — | US | disclosed |
| EP-1848470-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | Abbott Cardiovascular Systems, Inc. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2007097887-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007070630-A2 | IMPLANTABLE DEVICES FOR ACCELERATED HEALING | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| US-20070003589-A1 | Coatings for implantable medical devices containing attractants for endothelial cells | ADVANCED CARDIOVASCULAR SYSTEMS, INC. | 2007-01-04 | — | — | US | disclosed |
| WO-2006112932-A2 | COATINGS FOR IMPLANTABLE MEDICAL DEVICES CONTAINING ATTRACTANTS FOR ENDOTHELIAL CELLS | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |