Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL941017 | 1.00 | GSR (0.57) | GSRMMP2LTA4HPOLBKMT2A | |
| Ornithine Aketoglutarate SCHEMBL15539555 | 0.96 | GSR (0.50) | GSRMMP2LTA4HPOLBKMT2A | |
| Diphenylamine SCHEMBL593267 | 0.86 | GSR (0.67) | GSRMMP2LTA4HPOLBKMT2A | |
| Ornithine Aketoglutarate SCHEMBL11031186 | 0.84 | GSR (0.47) | GSRLTA4HPOLBKMT2ATDP1 | |
| Ornithine SCHEMBL11031187 | 0.84 | GSR (0.47) | GSRLTA4HPOLBKMT2ATDP1 | |
| Lysine SCHEMBL2473830 | 0.82 | GSR (0.49) | GSRMMP2LTA4HPOLBKMT2A | |
| Lysine SCHEMBL22684870 | 0.81 | GSR (0.54) | GSRMMP2LTA4HPOLBKMT2A | |
| Lysine SCHEMBL4305051 | 0.80 | GSR (0.57) | GSRMMP2LTA4HPOLBKMT2A | |
| Lysine SCHEMBL28214073 | 0.79 | GSR (0.91) | GSRMMP2POLBKMT2ATDP1 | |
| Cysteine SCHEMBL4970300 | 0.79 | PTGS1 (0.52) | MMP2LTA4HKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11591369-B2 | Alpha(v)beta(6) integrin-binding peptides and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210340181-A1 | ALPHA(V)BETA(6) INTEGRIN-BINDING PEPTIDES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | US | disclosed |
| EP-3846858-A1 | ALPHA(V)BETA(6) INTEGRIN-BINDING PEPTIDES AND METHODS OF USE THEREOF | The Regents of the University of California (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |