Cetirizine

Cetirizine

SCHEMBL41107

Cl.Cl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Cetirizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 4/20 1.00
DRD3 P35462 4/20 0.98
USP2 O75604 3/20 0.98
TDP1 Q9NUW8 3/20 0.98
HRH2 P25021 2/20 0.98
HTR2A P28223 2/20 0.98
HTR2B P41595 2/20 0.98
KCNH2 Q12809 2/20 0.98
SLC6A2 P23975 1/20 0.98
SLC6A4 P31645 1/20 0.98
SLC6A3 Q01959 1/20 0.98
TEK Q02763 1/20 0.98
DRD2 P14416 3/20 0.73
CYP2D6 P10635 2/20 0.73
ABCB11 O95342 1/20 0.73
CHRM2 P08172 1/20 0.73
ADRA2A P08913 1/20 0.73
ADRA2B P18089 1/20 0.73
ADRA2C P18825 1/20 0.73
DRD4 P21917 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Levocetirizine SCHEMBL144375 1.00 HRH1 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL41108 1.00 HRH1 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL17800801 1.00 HRH1 (1.00) HRH1DRD3USP2TDP1HRH2
Levocetirizine SCHEMBL2255374 1.00 HRH1 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL5520719 1.00 HRH1 (1.00) HRH1DRD3USP2TDP1HRH2
Levocetirizine SCHEMBL4914 0.99 DRD3 (1.00) HRH1DRD3USP2TDP1HRH2
Levocetirizine SCHEMBL5935097 0.99 DRD3 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL13724610 0.99 DRD3 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL4176 0.99 DRD3 (1.00) HRH1DRD3USP2TDP1HRH2
Cetirizine SCHEMBL2455487 0.99 DRD3 (1.00) HRH1DRD3USP2TDP1HRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 14909 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260148035-A1 COMPUTER OPERATED METHOD OF PROVIDING GUIDANCE TO A USER INNOVATE PRODUCT DESIGN LTD (GB) 2026-05-28 US claimed
CN-122086041-A Unmanned aerial vehicle collaborative operation method for mountain highway exploration 2026-05-26 CN claimed
CN-116776057-B Method for converting bent pipe data format YBC to XYZ 中国科学院沈阳自动化研究所 2026-05-19 CN claimed
US-20260115184-A1 DOSING REGIMEN FOR INJECTABLE CETIRIZINE JDP THERAPEUTICS LLC (US) 2026-04-30 US claimed
US-20260090584-A1 SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION SCIENTIFIC HORIZONS CONSULTING LLC (US) 2026-04-02 US claimed
EP-4654949-A1 USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS Hyloris Developments SA (BE) 2025-12-03 EP claimed
EP-4630401-A2 CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF Rutgers, the State University of New Jersey (US) 2025-10-15 EP claimed
US-12390416-B2 Chewable pharmaceutical dosage forms USpharma Ltd (US) 2025-08-19 US claimed
EP-4590371-A2 SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION Scientific Horizons consulting LLC (US) 2025-07-30 EP claimed
EP-4461908-B1 SELF ADJUSTING KEY DECODER BOVAL 7 OOD (BG) 2025-06-25 EP claimed
WO-2002047689-A2 USE OF CETIRIZINE OR EFLETIRIZINE FOR PREVENTING URTICARIA UCB, S.A. (BE) 2002-06-20 WO claimed
WO-2002038107-A2 STAT MODULATORS TULARIK INC. (US) 2002-05-16 WO claimed
WO-2001098291-A2 1,3-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND THEIR USE TO TREAT VCAM-1 MEDIATED DISORDERS ATHEROGENICS, INC. (US) 2001-12-27 WO claimed
US-20010051184-A1 METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES NEUVOLA II, LLC 2001-12-13 US claimed
WO-2001083517-A1 STAT4 AND STAT6 BINDING DIPEPTIDE DERIVATIVES TULARIK INC. (US) 2001-11-08 WO claimed
US-6258814-B1 INTRANASAL ADMINISTERING AS SEDATIVES SCHERING CORPORATION 2001-07-10 US claimed
EP-1109557-A2 A METHOD FOR PREVENTING THE ONSET OF ASTHMA UCB S.A. (BE) 2001-06-27 EP claimed
WO-2000070949-A1 METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES HENG MADALENE C Y (US) 2000-11-30 WO claimed
WO-2000010544-A2 A METHOD FOR PREVENTING THE ONSET OF ASTHMA UCB S.A. (BE) 2000-03-02 WO claimed
US-5993833-A Histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist in a cosmetic, pharmaceutical or dermatological composition SOCIETE L'OREAL S.A. (FR) 1999-11-30 US claimed