Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 15/20 | 0.38 |
| ▸ | PLK1 | P53350 | 14/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5936873 | 0.94 | BRD4 (0.38) | BRD4PLK1 | |
| SCHEMBL1288461 | 0.85 | BRD4 (0.40) | BRD4PLK1 | |
| SCHEMBL1288219 | 0.85 | PLK1 (0.44) | BRD4PLK1 | |
| SCHEMBL1288221 | 0.85 | PLK1 (0.44) | BRD4PLK1 | |
| SCHEMBL5937015 | 0.84 | BRD4 (0.45) | BRD4PLK1 | |
| SCHEMBL1288443 | 0.82 | PLK1 (0.47) | BRD4PLK1 | |
| SCHEMBL1688448 | 0.82 | PLK1 (0.46) | BRD4PLK1 | |
| SCHEMBL1288440 | 0.82 | PLK1 (0.47) | BRD4PLK1 | |
| SCHEMBL12320165 | 0.81 | PLK1 (0.43) | BRD4PLK1 | |
| SCHEMBL31712336 | 0.81 | PLK1 (0.47) | BRD4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115848-A1 | Inhibitors of Polo-Like Kinase | PLK1, POLR2E, POLR2H | BRD4 1149/4885PLK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.