Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.63 |
| ▸ | HRH1 | P35367 | 6/20 | 0.63 |
| ▸ | HTR2A | P28223 | 6/20 | 0.63 |
| ▸ | HTR2C | P28335 | 5/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD4 | P21917 | 4/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.63 |
| ▸ | HRH2 | P25021 | 3/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5946431 | 0.91 | MEN1 (0.68) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946367 | 0.89 | MEN1 (0.66) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946381 | 0.88 | MEN1 (0.65) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946361 | 0.88 | MEN1 (0.64) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946405 | 0.87 | MEN1 (0.68) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946357 | 0.86 | MEN1 (0.74) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946391 | 0.82 | DRD2 (0.64) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8204135 | 0.82 | MEN1 (0.63) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946392 | 0.81 | MEN1 (0.81) | MEN1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10194037 | 0.80 | HTR2C (0.79) | MEN1LMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063754-A1 | Methods of treating a sleep disorder | HYPNION, INC. | 2006-03-23 | — | — | US | disclosed |
| EP-0447857-B1 | A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5344828-A | Antiallergens; bronchial asthma | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0447857-A1 | A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1991-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063754-A1 | Methods of treating a sleep disorder | HCRTR2, HCRTR1, CHAT | MEN1 3844/4885LMNA 1582/4885CYP1A2 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.