Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 20/20 | 0.62 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185945 | 0.80 | GRIK1 (0.62) | GRIK1 | |
| SCHEMBL13234994 | 0.79 | MEN1 (0.59) | — | |
| SCHEMBL13235005 | 0.78 | TP53 (0.52) | — | |
| SCHEMBL3962638 | 0.77 | GRIK1 (0.72) | GRIK1GRIK2 | |
| SCHEMBL3957387 | 0.77 | GRIK1 (1.00) | GRIK1GRIK2 | |
| SCHEMBL3957527 | 0.76 | GRIK1 (1.00) | GRIK1GRIK2 | |
| SCHEMBL3960265 | 0.75 | GRIK1 (1.00) | GRIK1GRIK2 | |
| SCHEMBL3961542 | 0.74 | GRIK1 (1.00) | GRIK1GRIK2 | |
| SCHEMBL1462967 | 0.73 | GRIK1 (1.00) | GRIK1GRIK2 | |
| SCHEMBL3961219 | 0.73 | GRIK1 (1.00) | GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | claimed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | GRIK1 3295/4885GRIK2 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.