Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 16/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950123 | 0.80 | GRIK1 (0.62) | GRIK1 | |
| SCHEMBL3962633 | 0.77 | GRIK1 (1.00) | GRIK1NPC1RAB9A | |
| SCHEMBL6566353 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTALPLALPI | |
| SCHEMBL3962638 | 0.76 | GRIK1 (0.72) | GRIK1 | |
| SCHEMBL3957387 | 0.76 | GRIK1 (1.00) | GRIK1 | |
| SCHEMBL3957527 | 0.76 | GRIK1 (1.00) | GRIK1 | |
| SCHEMBL3960265 | 0.74 | GRIK1 (1.00) | GRIK1NPC1RAB9A | |
| SCHEMBL5950391 | 0.74 | GRIK1 (0.72) | GRIK1RAB9AMAPT | |
| SCHEMBL3961542 | 0.73 | GRIK1 (1.00) | GRIK1 | |
| SCHEMBL6565951 | 0.73 | ALPL (0.76) | NPC1RAB9AMAPTALPLALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |