Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.64 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10599343 | 0.88 | MAOB (0.70) | MAOBMRGPRX4NPC1ALDH1A1RAB9A | |
| SCHEMBL5249717 | 0.87 | NR1H4 (0.65) | MAOBNPC1RAB9AFFAR1NR1H4 | |
| SCHEMBL595941 | 0.83 | MAOB (0.59) | MAOBMRGPRX4NPC1ALDH1A1RAB9A | |
| SCHEMBL4404036 | 0.79 | MAOB (1.00) | MAOBMRGPRX4NPC1ALDH1A1RAB9A | |
| SCHEMBL26110078 | 0.78 | BACE1 (0.49) | MAOBMRGPRX4MAOANR1H4 | |
| SCHEMBL13469158 | 0.77 | MAOB (0.82) | MAOBMRGPRX4MAOAFFAR1FFAR4 | |
| SCHEMBL28390021 | 0.77 | MEN1 (0.71) | MAOBNPC1RAB9ANR1H4 | |
| SCHEMBL1400845 | 0.77 | GAA (0.62) | MAOBNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9538429 | 0.76 | MRGPRX4 (1.00) | MAOBMRGPRX4NPC1ALDH1A1RAB9A | |
| SCHEMBL8119011 | 0.76 | SIRT2 (0.64) | MAOBNPC1RAB9AFFAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| CN-102325531-A | Compounds and methods of use | GENENTECH INC | 2012-01-18 | — | — | CN | disclosed |
| US-20100190782-A1 | COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190782-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | MAOB 415/4885MRGPRX4 1304/4885NPC1 3311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.