Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 6/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941700 | 0.90 | S1PR3 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2288841 | 0.90 | S1PR3 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL5953439 | 0.90 | S1PR3 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL13942300 | 0.90 | S1PR3 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL13942299 | 0.89 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2284671 | 0.83 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL5953063 | 0.83 | S1PR1 (0.51) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL13165348 | 0.83 | S1PR1 (0.63) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2288579 | 0.83 | S1PR1 (0.63) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL13165354 | 0.83 | S1PR1 (0.63) | S1PR1S1PR3S1PR4S1PR5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173710-B2 | Bicyclic sphingosine 1-phosphate analogs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR3 3/4885S1PR4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.