Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | PRKCG | P05129 | 3/20 | 0.44 |
| ▸ | PRKCB | P05771 | 3/20 | 0.44 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | PRKCH | P24723 | 3/20 | 0.44 |
| ▸ | PRKCI | P41743 | 3/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2288841 | 1.00 | S1PR3 (0.52) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13942300 | 1.00 | S1PR3 (0.52) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13941700 | 1.00 | S1PR3 (0.52) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5952458 | 0.90 | S1PR1 (0.49) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL2010771 | 0.90 | S1PR1 (0.47) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13942299 | 0.86 | S1PR1 (0.50) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL14457017 | 0.86 | S1PR3 (0.50) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL5953063 | 0.84 | S1PR1 (0.51) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL2284671 | 0.84 | S1PR1 (0.51) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13165352 | 0.83 | S1PR1 (0.63) | S1PR3CYP3A4CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173710-B2 | Bicyclic sphingosine 1-phosphate analogs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-05-08 | — | — | US | disclosed |
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-08-11 | — | — | US | disclosed |
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-23 | — | — | US | disclosed |
| WO-2009023854-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-02-19 | — | — | WO | disclosed |
| US-20090042955-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-02-12 | — | — | US | disclosed |
| WO-2007092638-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042955-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR3 3/4885CYP3A4 4138/4885CYP2C8 4266/4885 |
| US-20110195936-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR3 3/4885CYP3A4 4138/4885CYP2C8 4266/4885 |
| US-20100240617-A1 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS | S1PR1, S1PR4, S1PR3 | S1PR3 3/4885CYP3A4 4138/4885CYP2C8 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.